| Tue Oct 11th,2005 | Alnwick Town | v | Billingham Town | 1 - 4 |
| Wed Nov 16th,2005 | Brandon United | v | Morpeth Town | 1 - 3 |
| Wed Oct 5th,2005 | Peterlee Newtown | v | Sunderland Nissan | 2 - 4 |
| Wed Sep 7th,2005 | Ryton | v | Crook Town | 1 - 3 |
| Tue Sep 6th,2005 | South Shields | v | North Shields | 2 - 0 |
| Wed Nov 23rd,2005 | West Allotment Celtic | v | Hebburn Town | 4 - 0 |
| Tue Oct 4th,2005 | West Auckland Town | v | Durham City | 3 - 1 |
| Wed Oct 5th,2005 | Whickham | v | Chester-le-Street | 2 - 0 |
| Tue Oct 18th,2005 | Whitley Bay | v | Northallerton Town | 2 - 4 |
| Tue Oct 18th,2005 | Ashington | v | Shildon | 2 - 1 |
| Wed Nov 9th,2005 | Bedlington Terriers | v | Horden C.W. | 3 - 2 |
| Wed Dec 21st,2005 | Consett | v | Billingham Town | 2 - 1 |
| Wed Nov 30th,2005 | Crook Town | v | Jarrow Roofing BCA | 2 - 4 |
| Wed Nov 30th,2005 | Darlington R.A. | v | South Shields | 3 - 2 |
| Tue Oct 25th,2005 | Dunston Federation | v | Washington | 5 - 4 |
| Tue Nov 15th,2005 | Esh Winning | v | Newcastle Blue Star | 4 - 4 |
| Newcastle Blue Star won 3-1 on penalties | ||||
| Wed Oct 26th,2005 | Kennek Ryhope C.A. | v | Norton & Stockton | 2 - 2 |
| Norton & Stockton won 3-2 on penalties | ||||
| Tue Dec 20th,2005 | Morpeth Town | v | Billingham Synthonia | 1 - 0 |
| Tue Nov 15th,2005 | Penrith | v | Sunderland Nissan | 3 - 2 |
| Tue Nov 15th,2005 | Prudhoe Town | v | Tow Law Town | 0 - 3 |
| Thu Nov 3rd,2005 | Seaham Red Star | v | Marske United | 5 - 2 |
| Wed Nov 16th,2005 | Thornaby | v | Northallerton Town | 4 - 1 |
| Wed Dec 21st,2005 | West Allotment Celtic | v | N/Cle Benfield B.P. | 0 - 1 |
| Tue Oct 25th,2005 | West Auckland Town | v | Spennymoor Town | 3 - 1 |
| Tue Oct 25th,2005 | Whickham | v | Guisborough Town | 5 - 0 |
| Tue Jan 24th,2006 | Ashington | v | Dunston Federation | 0 - 1 |
| Wed Feb 15th,2006 | Bedlington Terriers | v | Darlington R.A. | 0 - 2 |
| Tue Jan 24th,2006 | Jarrow Roofing BCA | v | Seaham Red Star | 4 - 1 |
| Tue Jan 24th,2006 | Morpeth Town | v | Tow Law Town | 4 - 1 |
| Wed Feb 15th,2006 | Norton & Stockton | v | Newcastle Blue Star | 1 - 2 |
| Wed Feb 22nd,2006 | Penrith | v | N/Cle Benfield B.P. | 2 - 1 |
| Wed Feb 15th,2006 | Thornaby | v | Consett | 1 - 5 |
| Tue Feb 28th,2006 | Whickham | v | West Auckland Town | 0 - 1 |
| Wed Mar 22nd,2006 | Darlington R.A. | v | Consett | 2 - 2 |
| Consett won 5-3 on penalties | ||||
| Tue Mar 7th,2006 | Jarrow Roofing BCA | v | Dunston Federation | 1 - 2 |
| Tue Mar 21st,2006 | Morpeth Town | v | West Auckland Town | 1 - 2 |
| Mon Mar 13th,2006 | Newcastle Blue Star | v | Penrith | 2 - 1 |
| Wed Apr 5th,2006 | Consett | v | Newcastle Blue Star | 0 - 1 |
| Tue Apr 4th,2006 | Dunston Federation | v | West Auckland Town | 4 - 0 |
| Fri May 5th,2006 | Newcastle Blue Star | v | Dunston Federation | 1 - 0 |
| aet | ||||
| Wed Oct 5th,2005 | Guisborough Town | v | Spennymoor Town | 1 - 2 |
| Tue Oct 11th,2005 | North Shields | v | Crook Town | 1 - 2 |
| Wed Oct 19th,2005 | Penrith | v | Alnwick Town | 3 - 0 |
| Tue Oct 4th,2005 | Prudhoe Town | v | Consett | 2 - 5 |
| Wed Jan 18th,2006 | Consett | v | Ryton | 4 - 3 |
| Wed Feb 15th,2006 | Crook Town | v | Whickham | 1 - 2 |
| Wed Jan 25th,2006 | Darlington R.A. | v | Kennek Ryhope C.A. | 6 - 3 |
| Wed Feb 8th,2006 | Hebburn Town | v | Northallerton Town | 0 - 1 |
| Wed Jan 18th,2006 | Norton & Stockton | v | Marske United | 2 - 0 |
| Wed Jan 18th,2006 | Peterlee Newtown | v | South Shields | 4 - 3 |
| Thu Jan 19th,2006 | Seaham Red Star | v | Spennymoor Town | 0 - 3 |
| Tue Jan 17th,2006 | Washington | v | Penrith | |
| Tie Awarded to Penrith | ||||
| Wed Mar 29th,2006 | Darlington R.A. | v | Whickham | 3 - 1 |
| Mon Mar 27th,2006 | Penrith | v | Consett | 4 - 1 |
| Wed Apr 5th,2006 | Peterlee Newtown | v | Northallerton Town | 1 - 11 |
| Tue Mar 7th,2006 | Spennymoor Town | v | Norton & Stockton | 2 - 4 |
| Mon Apr 24th,2006 | Northallerton Town | v | Penrith | 0 - 2 |
| Wed Apr 12th,2006 | Norton & Stockton | v | Darlington R.A. | 2 - 3 |
| Sat May 6th,2006 | Penrith | v | Darlington R.A. | 5 - 1 |